表面活性剂模板沸石在活性药物中间体生产中的应用。

Surfactant-templated zeolites for the production of active pharmaceutical intermediates.

机构信息

Laboratorio de Nanotecnología Molecular, Departamento de Química Inorgánica, Universidad de Alicante, Ctra. San Vicente-Alicante s/n, E-03690 San Vicente del Raspeig, Spain.

cMACS, Department of Microbial and Molecular Systems, KU Leuven-University of Leuven, Leuven Chem&Tech, Celestijnenlaan 200F, Post Box 2454, 3001 Heverlee, Belgium.

出版信息

Chem Commun (Camb). 2019 Nov 4;55(85):12869-12872. doi: 10.1039/c9cc06696a. Epub 2019 Oct 10.

DOI:10.1039/c9cc06696a

PMID:31599274

Abstract

A hierarchical USY zeolite has been produced using the surfactant-templating method and used as a catalyst for the production of two important active pharmaceutical ingredients. The presence of intracrystalline mesoporosity in the zeolite results in a significant increase in both the activity (up to 30 fold increase in TOF) and reusability for Friedel-Crafts alkylation and aldol condensation steps.

摘要

采用表面活性剂模板法合成了一种分级 USY 沸石，并将其用作两种重要的活性药物成分生产的催化剂。沸石中的晶内介孔的存在导致其在 Friedel-Crafts 烷基化和 aldol 缩合步骤中的活性（TOF 增加高达 30 倍）和可重复使用性显著提高。