Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Trends Parasitol. 2019 Nov;35(11):887-898. doi: 10.1016/j.pt.2019.08.005. Epub 2019 Oct 7.
Toxoplasma gondii infection in mice provides an excellent model for the study of CD8 T cell responses. Natural and engineered T. gondii antigens have led the way to understanding the factors regulating antigen presentation from vacuolar pathogens. T. gondii infection of resistant and sensitive mouse strains provides unique models to study both effective CD8 T cell function and protection in a well-controlled infection attributed to a novel T cell population, and T cell exhaustion in a progressing chronic infection. Additionally, the long-term persistence of the parasite in the brain provides a unique model of neurotropic infection used to study CD8 T cell entry, retention, and function in the brain. Here we discuss recent advances in each of these areas.
弓形虫感染小鼠为研究 CD8 T 细胞反应提供了极好的模型。天然和工程化的弓形虫抗原为理解从液泡病原体中进行抗原呈递的调节因素奠定了基础。抵抗和敏感的小鼠品系感染弓形虫提供了独特的模型，用于研究在新型 T 细胞群作用下的有效 CD8 T 细胞功能和保护作用，以及在进行性慢性感染中的 T 细胞耗竭。此外，寄生虫在大脑中的长期存在提供了一种独特的神经嗜性感染模型，用于研究 CD8 T 细胞在大脑中的进入、保留和功能。在这里，我们讨论了这些领域的最新进展。
