Ghenciu Laura Andreea, Hațegan Ovidiu Alin, Bolintineanu Sorin Lucian, Dănilă Alexandra-Ioana, Iacob Roxana, Stoicescu Emil Robert, Lupu Maria Alina, Olariu Tudor Rareș
Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.
Center for Translational Research and Systems Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.
Microorganisms. 2024 Jul 27;12(8):1541. doi: 10.3390/microorganisms12081541.
Toxoplasmosis, caused by the protozoan parasite (), presents a significant global health concern, particularly for immunocompromised individuals and congenitally infected newborns. Despite its widespread prevalence, there are limited data on seroprevalence and ocular toxoplasmosis in Romania. This review aims to summarize the research accomplished on the prevalence and epidemiology of human ocular toxoplasmosis in Romania. Ocular toxoplasmosis, a leading cause of infectious posterior uveitis worldwide, involves complex interactions between host immune responses and parasite factors. Clinically, it presents as focal necrotizing retinitis, characterized by active focal retinal lesions with adjacent chorioretinal scarring, often accompanied by vitreous inflammation and anterior chamber reactions. Diagnosis relies on clinical examination supported by fundus photography, optical coherence tomography (OCT), and serological assays. The authors followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards, conducting a literature review on PubMed, Google Scholar, and Scopus. Our focus was on ocular toxoplasmosis in Romania, and we used keywords and specific MeSH terms. Finally, 17 articles met all the criteria, as summarized in the PRISMA diagram. This study underscores the need for improved diagnostic methods, increased research efforts, and comprehensive public health education to mitigate the burden of toxoplasmosis and ocular toxoplasmosis in Romania.
弓形虫病由原生动物寄生虫（）引起，是一个重大的全球健康问题，对免疫功能低下的个体和先天性感染的新生儿尤为如此。尽管其广泛流行，但罗马尼亚关于血清阳性率和眼部弓形虫病的数据有限。本综述旨在总结罗马尼亚人类眼部弓形虫病患病率和流行病学方面已完成的研究。眼部弓形虫病是全球感染性后葡萄膜炎的主要病因，涉及宿主免疫反应和寄生虫因素之间的复杂相互作用。临床上，它表现为局灶性坏死性视网膜病变，其特征是活动性局灶性视网膜病变伴有相邻脉络膜视网膜瘢痕形成，常伴有玻璃体炎症和前房反应。诊断依靠眼底摄影、光学相干断层扫描（OCT）和血清学检测支持的临床检查。作者遵循系统评价和Meta分析的首选报告项目（PRISMA）标准，在PubMed、谷歌学术和Scopus上进行文献综述。我们关注的是罗马尼亚的眼部弓形虫病，并使用了关键词和特定的医学主题词（MeSH）。最后，17篇文章符合所有标准，如PRISMA图中总结的那样。本研究强调需要改进诊断方法、加大研究力度并开展全面的公共卫生教育，以减轻罗马尼亚弓形虫病和眼部弓形虫病的负担。
