Hu Yanling, Yu Liyao, Xia Fen, Liang Fengqi, Cheng Chao, Huang Yuhua, Xiao Linqi
Department of Gynaecology and Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Exp Ther Med. 2019 Nov;18(5):3588-3594. doi: 10.3892/etm.2019.7941. Epub 2019 Aug 26.
Effect of laparoscopic myomectomy on the serum levels of interleukin-6 (IL-6) and total antioxidant capacity (TAC), and the ovarian function of patients with uterine fibroids was studied. Ninety patients with uterine fibroids admitted to The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, from March 2013 to July 2014, were randomly divided into the experimental group (n=45) and the control group (n=45). The experimental group was treated with laparoscopic myomectomy, and the control group was treated with abdominal myomectomy. ELISA was used for detecting IL-6 and TAC content. Radioimmunoassay (RIA) was used for detecting serum ovarian function indicators, including estradiol (E), follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Patients in the experimental group had significantly lower intraoperative blood loss, postoperative exhaust time, number of days to recovery and return to work, number of intraoperative fibroids removed, and length of stay than those in the control group (P<0.05). TAC expression level was significantly higher in the experimental group than that in the control group, on the 1st, 3rd and 5th day after surgery (P<0.05), while IL-6 expression was significantly lower in the experimental group than that in the control group at the same time points (P<0.05). FSH and LH expression levels were significantly lower in the experimental group than those in the control group (P<0.05) at 1, 3 and 6 months after surgery, while E expression level was significantly higher in the experimental group than that in the control group at the same time points (P<0.05). The incidence of postoperative complications of patients in the experimental group was significantly lower than that in the control group (P<0.05). Patients in the experimental group had significantly higher successful pregnancy rate than those in the control group (χ=6.75, P<0.05). Reducing its effect on ovarian function, serum pain index and oxidative damage index of patients with uterine fibroid, laparoscopic myomectomy also reduces the incidence of postoperative complications and increases the pregnancy rate.
研究了腹腔镜子宫肌瘤切除术对子宫肌瘤患者血清白细胞介素-6（IL-6）水平、总抗氧化能力（TAC）及卵巢功能的影响。选取2013年3月至2014年7月在华中科技大学同济医学院附属武汉中心医院收治的90例子宫肌瘤患者，随机分为实验组（n = 45）和对照组（n = 45）。实验组采用腹腔镜子宫肌瘤切除术治疗，对照组采用开腹子宫肌瘤切除术治疗。采用酶联免疫吸附测定法（ELISA）检测IL-6和TAC含量。采用放射免疫分析法（RIA）检测血清卵巢功能指标，包括雌二醇（E）、促卵泡生成素（FSH）和促黄体生成素（LH）。实验组患者术中出血量、术后排气时间、恢复及重返工作天数、术中切除肌瘤数量和住院时间均显著低于对照组（P<0.05）。术后第1、3和5天，实验组TAC表达水平显著高于对照组（P<0.05），而同一时间点实验组IL-6表达显著低于对照组（P<0.05）。术后1、3和6个月，实验组FSH和LH表达水平显著低于对照组（P<0.05），而同一时间点实验组E表达水平显著高于对照组（P<0.05）。实验组患者术后并发症发生率显著低于对照组（P<0.05）。实验组患者成功妊娠率显著高于对照组（χ=6.75，P<0.05）。腹腔镜子宫肌瘤切除术在降低对患者卵巢功能、血清疼痛指数和氧化损伤指数影响的同时，还降低了术后并发症发生率并提高了妊娠率。
