Hypermethylation of promoter plays oncogenic roles in development of clear cell renal cell carcinoma.

Although the inactivation of plays oncogenic roles in tumorigenesis, regulation mechanism is rarely studied in clear cell renal cell carcinoma (RCC). Thus, we aimed to investigate the mechanism of inactivation and explore the tumor suppressing roles of in the development of clear cell RCC. We verified that hypermethylation of the promoter was correlated with decreased expression of by multi-omics analysis based on the TCGA database. This result was further confirmed in our own tumor tissues. Moreover, inhibited the ability of proliferation and invasion of RCC cells . Consistent with this, overexpressing virtually inhibited the xenograft tumor growth of ACHN cells . Finally we found that promoted cell apoptosis and cellular cycle arrest in G2/M. In conclusion, our study confirms that the hypermethylation of promoters plays oncogenic roles by the transcription inhibition of in RCC, and the tumor suppressor gene inhibits RCC cell vitality and