Yu Dan-Dan, Liao Xing, Xie Yan-Ming, Li Hui-Min, Zhang Yi-Li, Wang Gui-Qian, Zhao Jun
Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.
School of Traditional Chinese Medicine,Beijing University of Chinese Medicine Beijing 100029,China.
Zhongguo Zhong Yao Za Zhi. 2019 Jul;44(14):2914-2925. doi: 10.19540/j.cnki.cjcmm.20190513.502.
To systematically review the efficacy and safety of Huoxiang Zhengqi Pills combined with Western medicine in the treatment of acute gastroenteritis. Four Chinese databases( CNKI,VIP,Wan Fang,Sino Med) and three English databases( Cochrane Library,Medline,EMbase) were systematically and comprehensively searched from the database establishment to April 2019 to collect the randomized controlled trials( RCTs) about the treatment of acute gastroenteritis with Huoxiang Zhengqi Pills combined with Western medicine. Two investigators independently performed literature screening,data extraction and bias risk assessment. Rev Man 5. 3 software was used for data analysis. A total of 316 articles were retrieved and finally 44 studies were included in this study,involving 4153 patients. The overall quality of the included studies was generally low. Meta-analysis results showed that in the total clinical effective rate,Huoxiang Zhengqi Pills combined with conventional treatment or norfloxacin tablets was superior to conventional treatment or norfloxacin tablets alone. In terms of the time for improving clinical symptoms,Huoxiang Zhengqi Pills combined with conventional treatment or norfloxacin tablets could better relieve fever than conventional treatment or norfloxacin tablets alone. In terms of incidence of adverse reactions,there was no statistical difference between Huoxiang Zhengqi Pills combined with conventional treatment and conventional treatment alone. Other outcome measures were affected by various factors( such as inclusion of only 1 study or excessive heterogeneity among studies) and could not be concluded. Due to the limitations of the quality and quantity of included studies,this conclusion still needs to be verified by more high quality researches.
系统评价藿香正气丸联合西药治疗急性胃肠炎的疗效及安全性。从各数据库建库至2019年4月，系统全面检索4个中文数据库（中国知网、维普、万方、中国生物医学文献数据库）和3个英文数据库（考克兰图书馆、医学期刊数据库、荷兰医学文摘数据库），收集藿香正气丸联合西药治疗急性胃肠炎的随机对照试验（RCT）。由两名研究者独立进行文献筛选、数据提取及偏倚风险评估。采用Rev Man 5.3软件进行数据分析。共检索到316篇文献，最终纳入44项研究，涉及4153例患者。纳入研究的整体质量普遍较低。Meta分析结果显示，在总临床有效率方面，藿香正气丸联合常规治疗或诺氟沙星片优于单纯常规治疗或诺氟沙星片。在改善临床症状时间方面，藿香正气丸联合常规治疗或诺氟沙星片较单纯常规治疗或诺氟沙星片能更好地缓解发热。在不良反应发生率方面，藿香正气丸联合常规治疗与单纯常规治疗之间无统计学差异。其他结局指标受多种因素影响（如仅纳入1项研究或研究间异质性过大），无法得出结论。由于纳入研究的质量和数量有限，该结论仍需更多高质量研究验证。
