Xue Zhen-Zhen, Zhang Rui-Xian, Yang Bin
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
Zhongguo Zhong Yao Za Zhi. 2019 Sep;44(17):3601-3607. doi: 10.19540/j.cnki.cjcmm.20190701.104.
Magnoliae Officinalis Cortex( MOC),the stem bark of Magnolia officinalis( MO) and M. officinalis var. biloba( MOB),is a main ingredient in more than 200 types of Chinese formulae commonly used in clinics. MO and MOB are widely distributed in China,from Sichuan of the west to Zhejiang province of the east and from Shannxi province in the north to Guangxi province in the south. This review summarizes new findings on geo-heralism of MOC concerning textual research,plants taxonomy,genetic study,chemical study,and pharmacological activity,resulting in the following views. ①The original plants of MOC are suggested to be divided into three geographic clans according to the form of leave and the result of genetic research; ②Concentrations of magnolol,honokiol,magnoloside A,magnoloside B,magnoflorine,and β-eudesmol in samples collected from different geographic areas are varied;③Samples of MOC produced in Hubei and Sichuan were traditionally regarded as Dao-di herbs,which were called Chuanpo,and the pure haplotype of MOC produced in Hubei may become a genetic index.
厚朴，为木兰科植物厚朴及凹叶厚朴的干燥干皮，是临床常用200多种中药方剂中的主要成分。厚朴和凹叶厚朴在中国分布广泛，西至四川，东至浙江，北至陕西，南至广西。本综述总结了厚朴道地性在文献考证、植物分类学、遗传学研究、化学研究和药理活性方面的新发现，得出以下观点。①根据叶形和遗传学研究结果，厚朴的原植物建议分为三个地理类群；②不同地理区域采集的样品中厚朴酚、和厚朴酚、厚朴苷A、厚朴苷B、木兰碱和β-桉叶醇的含量有所不同；③湖北和四川产的厚朴样品传统上被视为道地药材，称为川朴，湖北产厚朴的纯合单倍型可能成为一个遗传指标。
