National Center for Natural Product Research, School of Pharmacy, University of Mississippi, University, MS, USA.
Drug Discovery Division, Southern Research, Birmingham, AL, UK.
J Diet Suppl. 2021;18(1):1-16. doi: 10.1080/19390211.2019.1674996. Epub 2019 Oct 11.
Raspberry ketone (RK)-an aromatic compound found mostly in red raspberries () is widely used as an over the counter product for weight loss. The present study was conducted to determine adverse effects associated with RK in obese and health-compromised obese mice. Two sets of experiments were conducted on normal obese and health-compromised obese mice treated with RK for a duration of 10 days. Obese conditions were induced by feeding mice a high fat diet for 10 weeks, while the health compromised obese mouse model was developed by a single intraperitoneal injection of a nontoxic dose of lipopolysaccharide (LPS) (6 mg/kg) to obese mice. Results showed that RK (165, 330, and 500 mg/kg) under obese as well as health-compromised condition retarded the gain in body weights as compared to the control groups. RK at doses 330 and 500 mg/kg resulted in 67.6 and 50% mortality, respectively in normal obese mice and 70% mortality was observed in health-compromised obese mice treated with RK at 500 mg/kg. At higher doses deaths were observed earlier than those given lower doses of RK. Significant elevations in blood alanine transaminase (ALT) were also observed with RK treatment in obese mice. Blood glucose levels were significantly elevated in all groups of mice treated with RK. This study suggests that higher doses of RK may cause adverse effects in health compromised conditions. Under these conditions, prolonged use of RK, especially in high doses, may pose a health hazard.
覆盆子酮（RK）-一种主要存在于红覆盆子中的芳香化合物，被广泛用作减肥的非处方药。本研究旨在确定 RK 在肥胖和健康受损肥胖小鼠中相关的不良反应。在正常肥胖和健康受损肥胖小鼠上进行了两组实验，用 RK 处理 10 天。肥胖条件通过用高脂肪饮食喂养小鼠 10 周来诱导，而健康受损肥胖小鼠模型通过单次腹腔内注射非毒性剂量的脂多糖（LPS）（6mg/kg）来开发肥胖小鼠。结果表明，与对照组相比，RK（165、330 和 500mg/kg）在肥胖和健康受损条件下均减缓了体重增加。在正常肥胖小鼠中，RK 剂量为 330 和 500mg/kg 分别导致 67.6%和 50%的死亡率，而在接受 500mg/kg RK 治疗的健康受损肥胖小鼠中观察到 70%的死亡率。在较高剂量下，死亡发生得比给予较低剂量 RK 时更早。在肥胖小鼠中用 RK 治疗也观察到血液丙氨酸转氨酶（ALT）显著升高。用 RK 处理的所有小鼠组的血糖水平均显著升高。本研究表明，较高剂量的 RK 可能在健康受损条件下引起不良反应。在这些条件下，长时间使用 RK，特别是高剂量，可能会对健康造成危害。
