Rao Shailaja, Kurakula Mallesh, Mamidipalli Nagarjuna, Tiyyagura Papireddy, Patel Bhaumik, Manne Ravi
Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA.
Plants (Basel). 2021 Jun 29;10(7):1323. doi: 10.3390/plants10071323.
Raspberry ketone (RK) is an aromatic phenolic compound naturally occurring in red raspberries, kiwifruit, peaches, and apples and reported for its potential therapeutic and nutraceutical properties. Studies in cells and rodents have suggested an important role for RK in hepatic/cardio/gastric protection and as an anti-hyperlipidemic, anti-obesity, depigmentation, and sexual maturation agent. Raspberry ketone-mediated activation of peroxisome proliferator-activated receptor-α (PPAR-α) stands out as one of its main modes of action. Although rodent studies have demonstrated the efficacious effects of RK, its mechanism remains largely unknown. In spite of a lack of reliable human research, RK is marketed as a health supplement, at very high doses. In this review, we provide a compilation of scientific research that has been conducted so far, assessing the therapeutic properties of RK in several disease conditions as well as inspiring future research before RK can be considered safe and efficacious with limited side effects as an alternative to modern medicines in the treatment of major lifestyle-based diseases.
覆盆子酮（RK）是一种芳香酚类化合物，天然存在于红树莓、猕猴桃、桃子和苹果中，并因其潜在的治疗和营养保健特性而被报道。细胞和啮齿动物研究表明，RK在肝脏/心脏/胃部保护方面具有重要作用，并且作为一种抗高血脂、抗肥胖、色素沉着减退和性成熟剂。覆盆子酮介导的过氧化物酶体增殖物激活受体-α（PPAR-α）激活是其主要作用模式之一。尽管啮齿动物研究已经证明了RK的有效作用，但其机制在很大程度上仍然未知。尽管缺乏可靠的人体研究，但RK仍作为一种高剂量的健康补充剂在市场上销售。在这篇综述中，我们汇总了迄今为止进行的科学研究，评估了RK在几种疾病状况下的治疗特性，并为未来的研究提供了启发，直到RK可以被认为是安全有效的，且副作用有限，可作为治疗主要生活方式相关疾病的现代药物的替代品。
