Child Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.
School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia.
J Stud Alcohol Drugs. 2019 Sep;80(5):515-523.
The purpose of this study was to undertake a comprehensive review to identify all the available preclinical and clinical literature investigating cardiovascular and renal outcomes in offspring with prenatal alcohol exposure (PAE).
We used a systematic review methodology to survey published clinical and preclinical studies investigating cardio-renal outcomes in offspring with PAE. Literature was systematically searched across four electronic databases and titles/abstracts screened against specific inclusion/exclusion criteria.
A total of 22 studies (9 clinical and 13 preclinical) were included. It was found that PAE can affect aspects of cardiovascular and renal function, including blood pressure, heart rate control, heart function, and urinary excretion. However, there remain very few clinical studies in this area, and those contained in this review were typically of poor quality and/or had small sample sizes.
Despite the limited research and variable findings across studies, current studies provide preliminary evidence of cardio-renal dysfunction in offspring with PAE.
本研究旨在进行全面综述，以确定所有关于产前酒精暴露（PAE）对子代心血管和肾脏结局的临床前和临床文献。
我们使用系统综述方法，调查了已发表的临床前和临床研究，以研究 PAE 对子代心脏肾脏结局的影响。文献在四个电子数据库中进行了系统检索，并根据具体的纳入/排除标准对标题/摘要进行了筛选。
共纳入 22 项研究（9 项临床研究和 13 项临床前研究）。结果发现，PAE 可影响心血管和肾功能的各个方面，包括血压、心率控制、心脏功能和尿排泄。然而，该领域的临床研究非常少，本综述中包含的研究通常质量较差，或样本量较小。
尽管研究数量有限，且研究结果存在差异，但目前的研究为 PAE 对子代心脏肾脏功能障碍提供了初步证据。
