牙龈与关节：二者是否存在关联？第二部分：生物学联系。

Gums and joints: is there a connection? Part two: the biological link.

机构信息

Periodontal Research Group, Birmingham Dental School, 5 Mill Pool Way, Edgbaston, Birmingham, B5 7EG, UK.

Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.

出版信息

Br Dent J. 2019 Oct;227(7):611-617. doi: 10.1038/s41415-019-0723-7.

DOI:10.1038/s41415-019-0723-7

PMID:31605072

Abstract

Rheumatoid arthritis (RA) and periodontitis (PD) are inflammatory diseases characterised by an exacerbated immune-inflammatory reaction that leads to the destruction of bone and other connective tissues that share numerous similarities. Although a significant and independent association between these two conditions has been described, the pathophysiological processes that may explain this relationship remain unknown and multiple theories have been proposed. This review presents the most important theories currently proposed to explain the biological link between RA and PD.

摘要

类风湿关节炎（RA）和牙周炎（PD）是炎症性疾病，其特征为免疫炎症反应加剧，导致骨和其他结缔组织破坏，这些疾病有许多相似之处。尽管已经描述了这两种疾病之间存在显著且独立的关联，但可能解释这种关系的病理生理过程仍不清楚，并提出了多种理论。本文综述了目前提出的解释 RA 和 PD 之间生物学联系的最重要理论。