[过敏性和非过敏性鼻炎儿童及青少年呼出一氧化氮的比较分析]

[Comparative analysis of exhaled nitric oxide in children and teenagers with allergic and non-allergic rhinitis].

作者信息

Saranz Ricardo, Lozano Alejandro, Lozano Natalia Andrea, Alegre Graciela, Sasia Laura Verónica, Cóncari Eugenia, Robredo Paula, Ponzio Marina, Cruz Álvaro

机构信息

Universidad Católica de Córdoba, Clínica Universitaria Reina Fabiola, Servicio de Alergia e Inmunología, Córdoba, Argentina.

出版信息

Rev Alerg Mex. 2019 Jul-Sep;66(3):272-281. doi: 10.29262/ram.v66i3.583.

DOI:10.29262/ram.v66i3.583

PMID:31606010

Abstract

BACKGROUND

There is subclinical bronchial inflammation in patients with allergic rhinitis (AR). There is less evidence of inflammation of the lower airway in non-allergic rhinitis (NAR).

OBJECTIVE

To investigate the inflammation of the lower airway by exhaled nitric oxide (FeNO) in patients with AR and NAR without asthma and its link to lung function, the severity of rhinitis, and biomarkers of atopy.

METHODS

A cross-sectional study of patients aged 6 to 18 years, with AR or NAR without asthma. Spirometry, serum IgE, blood eosinophil count and FeNO were carried out. Rhinitis was classified according to the ARIA guide.

RESULTS

Forty patients were included; 28 with AR and 12 with NAR. Patients with AR showed higher FeNO levels (medium 36.5 ppb; range 5-114) than those with NAR (medium 7 ppb; range 5-24) (p = 0.0011). Elevated FeNO was linked to spirometric abnormalities [OR= 7.14 (95 % CI 1.04-49.04), p = 0.049)]. In AR, there was correlation between FeNO and blood eosinophils (r = 0.41, p = 0-33).

CONCLUSIONS

Both children and teenagers with AR showed higher FeNO than patients with NAR, which was correlated with blood eosinophilia and altered lung function.

摘要

背景

变应性鼻炎（AR）患者存在亚临床支气管炎症。非变应性鼻炎（NAR）患者下气道炎症的证据较少。

目的

通过呼出一氧化氮（FeNO）研究无哮喘的AR和NAR患者的下气道炎症及其与肺功能、鼻炎严重程度和特应性生物标志物的关系。

方法

对6至18岁的AR或NAR且无哮喘的患者进行横断面研究。进行肺量计检查、血清IgE、血液嗜酸性粒细胞计数和FeNO检测。根据ARIA指南对鼻炎进行分类。

结果

纳入40例患者；28例AR患者和12例NAR患者。AR患者的FeNO水平（中位数36.5 ppb；范围5 - 114）高于NAR患者（中位数7 ppb；范围5 - 24）（p = 0.0011）。FeNO升高与肺量计异常相关[比值比= 7.14（95%可信区间1.04 - 49.04），p = 0.049]。在AR中，FeNO与血液嗜酸性粒细胞之间存在相关性（r = 0.41，p = 0.033）。