Laatikainen T, Räisänen I, Tulenheimo A, Salminen K
Fertil Steril. 1985 Aug;44(2):206-9.
beta-Endorphin (beta-E) takes part in the regulation of luteinizing hormone (LH) and prolactin secretion, but little is known about its role in the menstrual cycle. Using a specific assay, plasma concentration of beta-E was followed in healthy women in the periovulatory period and before and during menstruation. The mean concentration of beta-E in the eight women studied showed an increase at the midcycle, being 3.2 +/- 0.5 (standard error) pmol/l on day LH -1 and rising to 4.6 +/- 0.7 pmol/l on day LH 0 and further to 7.5 +/- 1.2 pmol/l on day LH +1. Thereafter, the mean beta-E level remained at 5.3 +/- 0.8 pmol/l and 5.2 +/- 0.4 pmol/l on days LH +2 and LH +3, respectively. Ten additional women were studied before and during menstruation. The highest mean plasma concentration of beta-E, 5.1 +/- 0.9 pmol/l, was found at the onset of menstruation, declining to 3.3 +/- 0.6 pmol/l and 2.9 +/- 0.6 pmol/l on the second and fifth days of menstruation, respectively. These findings suggest that beta-E secretion increases at the time of ovulation. At the onset of menstruation, pain may increase endorphin secretion.
β-内啡肽（β-E）参与促黄体生成素（LH）和催乳素分泌的调节，但对其在月经周期中的作用了解甚少。采用特定检测方法，对健康女性排卵期前后以及月经前和月经期间的血浆β-E浓度进行跟踪监测。在研究的8名女性中，β-E的平均浓度在月经周期中期有所升高，在LH -1日为3.2±0.5（标准误）pmol/L，在LH 0日升至4.6±0.7 pmol/L，在LH +1日进一步升至7.5±1.2 pmol/L。此后，在LH +2日和LH +3日，β-E的平均水平分别维持在5.3±0.8 pmol/L和5.2±0.4 pmol/L。另外10名女性在月经前和月经期间接受了研究。β-E的最高平均血浆浓度为5.1±0.9 pmol/L，出现在月经开始时，在月经第二天和第五天分别降至3.3±0.6 pmol/L和2.9±0.6 pmol/L。这些发现表明，排卵时β-E分泌增加。月经开始时，疼痛可能会增加内啡肽的分泌。
