Vrbicky K W, Baumstark J S, Wells I C, Hilgers T W, Kable W T, Elias C J
Fertil Steril. 1982 Dec;38(6):701-4.
The possibility that beta-endorphin, an endogenous opiate, is involved in the regulation of the menstrual cycle was examined. Daily serum beta-endorphin levels, in conjunction with luteinizing hormone, progesterone, and 17 beta-estradiol were measured during 26 hormonally normal menstrual cycles. Twenty-one cycles showed a preovulatory peak and postovulatory trough of beta-endorphin, 2 cycles had a postovulatory peak, and 3 had a postovulatory peak with sustained elevation. The raw data were standardized by conversion to "Z-scores," and the composite values were computed for each of the three classes described above. Significance within these three classes was assessed using a one-way analysis of variance with an F-ratio at 95% confidence limits. The composite plot of the 26 cycles showed a statistically significant preovulatory peak occurring 2 days prior to the luteinizing hormone surge and a postovulatory trough of beta-endorphin 5 days later. These results suggest that beta-endorphins play a significant role in the neurochemical mechanisms of gonadotropin release.
研究了内源性阿片类物质β-内啡肽参与月经周期调节的可能性。在26个激素水平正常的月经周期中，每天测量血清β-内啡肽水平，并同时测量促黄体生成素、孕酮和17β-雌二醇。21个周期显示β-内啡肽在排卵前出现峰值，排卵后出现低谷；2个周期在排卵后出现峰值；3个周期在排卵后出现峰值并持续升高。通过转换为“Z分数”对原始数据进行标准化，并为上述三类中的每一类计算综合值。使用95%置信限的F比率的单向方差分析评估这三类中的显著性。26个周期的综合图显示，在促黄体生成素激增前2天出现具有统计学意义的排卵前峰值，5天后出现β-内啡肽的排卵后低谷。这些结果表明，β-内啡肽在促性腺激素释放的神经化学机制中起重要作用。
