4th Department of Internal Medicine, School of Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital of Thessaloniki, Konstantinoupoleos, Thessaloniki, Greece.
4th Department of Internal Medicine, School of Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital of Thessaloniki, Konstantinoupoleos, Thessaloniki, Greece.
Ann Hepatol. 2020 Mar-Apr;19(2):134-144. doi: 10.1016/j.aohep.2019.07.013. Epub 2019 Sep 23.
The association of non-alcoholic fatty liver disease (NAFLD) with several other diseases has gained increased interest during the recent years. Among them, the association with chronic kidney disease (CKD) has emerged as an important one regarding both its prevalence and significance. The early recognition of this association is important for the prognosis of patients with NAFLD and CKD. Apart from early diagnosis, the accurate assessment of renal function is also crucial in the clinical practice of hepatologists. Several methods have been used in the literature for the evaluation of kidney function in patients with NAFLD up to now. In this respect, calculators (or formulas) for the estimation of Glomerular Filtration Rate (eGFR) and Albumin to Creatinine Ratio (ACR) are simple, practical and easily available methods for this purpose. The aim of this review is to report on the epidemiology and pathophysiology of the relationship between NAFLD and CKD and to describe the different methods of kidney function assessment in patients with NAFLD. The collection of all relevant data regarding this association will provide hepatologists with pertinent knowledge on this topic and allow them to use the most accurate methods for the assessment of kidney function in these patients in their clinical practice.
非酒精性脂肪性肝病（NAFLD）与其他几种疾病的关联近年来引起了越来越多的关注。其中，与慢性肾脏病（CKD）的关联因其普遍性和重要性而成为一个重要的问题。早期认识到这种关联对于 NAFLD 和 CKD 患者的预后很重要。除了早期诊断外，准确评估肾功能在肝病学家的临床实践中也至关重要。迄今为止，文献中已经使用了多种方法来评估 NAFLD 患者的肾功能。在这方面，肾小球滤过率（eGFR）和白蛋白与肌酐比值（ACR）的计算器（或公式）是用于此目的的简单、实用且易于获得的方法。本综述的目的是报告 NAFLD 和 CKD 之间关系的流行病学和病理生理学，并描述评估 NAFLD 患者肾功能的不同方法。收集关于这种关联的所有相关数据将为肝病学家提供关于这个主题的相关知识，并使他们能够在临床实践中为这些患者评估肾功能时使用最准确的方法。
