胰岛素治疗对链脲佐菌素诱导的糖尿病大鼠离体灌注肝脏中酮体生成及肉碱-棕榈酰转移酶（CPT）活性的影响。

Effects of insulin treatment on ketone body production and carnitine-palmitoyl-transferase (CPT) activity in the isolated perfused liver from streptozotocin diabetic rats.

作者信息

Tessari P, Meneghel A, Avogaro A, Nosadini R, Del Prato S, Tiengo A

出版信息

Horm Metab Res. 1985 Jun;17(6):271-4. doi: 10.1055/s-2007-1013517.

DOI:10.1055/s-2007-1013517

Abstract

The aim of the present paper was to evaluate the effects of in vivo insulin treatment of streptozotocin (SZ) diabetic rats on the metabolism of the isolated, perfused liver. Perfused livers from SZ-diabetic rats showed a higher ketone body production and a higher mitochondrial carnitine-palmitoyl-transferase (CPT) activity than controls, while triglyceride (TG) output and free-fatty-acid (FFA) uptake were significantly reduced. In vivo insulin treatment normalized both the ketogenic capacity of the liver and CPT activity, while FFA uptake and TG production were still lower than in controls. A significant correlation was found between total ketone body output and CPT activity. We suggest that In vivo insulin treatment of SZ-diabetic rats can modulate the ketogenic capacity of the isolated, perfused liver.

摘要

本文的目的是评估体内胰岛素治疗链脲佐菌素（SZ）糖尿病大鼠对离体灌注肝脏代谢的影响。与对照组相比，SZ糖尿病大鼠的灌注肝脏显示出更高的酮体生成和更高的线粒体肉碱-棕榈酰转移酶（CPT）活性，而甘油三酯（TG）输出和游离脂肪酸（FFA）摄取显著降低。体内胰岛素治疗使肝脏的生酮能力和CPT活性均恢复正常，而FFA摄取和TG生成仍低于对照组。发现总酮体输出与CPT活性之间存在显著相关性。我们认为，体内胰岛素治疗SZ糖尿病大鼠可调节离体灌注肝脏的生酮能力。