Gäbel H, Bitter-Suermann H, Henriksson C, Säve-Söderbergh J, Lundholm K, Brynger H
Horm Metab Res. 1985 Jun;17(6):275-80. doi: 10.1055/s-2007-1013518.
Spontaneous diabetes in the domestic pig, an animal suitable for metabolic and endocrine studies and for experimental surgery, is extremely rare. In this study we have compared the diabetogenic response of various doses of streptozotocin in comparison to surgically induced diabetes. Streptozotocin in a low dose, 35 mg/kg body weight did not influence glucose metabolism while an intermediate dose, 85 mg/kg, resulted in a transient diabetic reaction. Streptozotocin, 100-150 mg/kg body weight, caused a complete and permanent diabetes. Animals made diabetic by means of pancreatectomy did not survive more than 10 days due to their poor general condition and diabetes. Streptozotocin induced diabetic animals survived with insulin treatment up to seven months. The results show that juvenile pigs made diabetic with 100-150 mg/kg body weight of streptozotocin may be useful in experimental work on glucose-, insulin- and C-peptide-metabolism in a large animal. Therefore it is potentially useful in pancreatic transplantation research.
家猪是一种适合进行代谢和内分泌研究以及实验手术的动物，其自发性糖尿病极为罕见。在本研究中，我们比较了不同剂量链脲佐菌素与手术诱导糖尿病的致糖尿病反应。低剂量（35毫克/千克体重）的链脲佐菌素不影响葡萄糖代谢，而中等剂量（85毫克/千克）会导致短暂的糖尿病反应。100 - 150毫克/千克体重的链脲佐菌素会引发完全且永久性的糖尿病。通过胰腺切除术致糖尿病的动物由于总体状况不佳和糖尿病，存活时间不超过10天。链脲佐菌素诱导的糖尿病动物在胰岛素治疗下可存活长达七个月。结果表明，用100 - 150毫克/千克体重的链脲佐菌素使幼年猪患糖尿病，可能有助于在大型动物中进行关于葡萄糖、胰岛素和C肽代谢的实验工作。因此，它在胰腺移植研究中可能具有潜在用途。
