Dickstein R, Kiremidjian-Schumacher L, Stotzky G
Immunopharmacology. 1985 Jun;9(3):127-39. doi: 10.1016/0162-3109(85)90008-6.
In vivo exposure of mice to lidocaine (0.25 mg/10 g body weight 4 times a day for 7 days) resulted in impairment of immunocompetent cell function. Spleen lymphocytes removed from animals immediately and 3 days after lidocaine exposure showed changes in their surface charge properties, inhibition of blastogenesis in response to concanavalin A and lipopolysaccharide, and inhibition of antigen-stimulated activation as measured by the mixed lymphocyte reaction. Lymphocytes from animals sensitized to keyhole limpet hemocyanin showed a significantly lower capacity to produce macrophage migration inhibitory factor 8 days after termination of exposure to lidocaine. Animals exposed to the drug were unable to accumulate an adequate number of immunocompetent cells at the site of challenge with a foreign substance (i.e. dextran), and the ability of the animals to destroy tumor cells nonspecifically and specifically was also impaired. The results indicated that chronic exposure to lidocaine resulted in impairment of lymphocyte function, even in the subsequent absence of the drug, and in significant changes in the expression of the immune response.
给小鼠进行体内利多卡因暴露（0.25毫克/10克体重，每天4次，共7天）导致免疫活性细胞功能受损。在利多卡因暴露后立即以及3天从动物体内取出的脾淋巴细胞显示其表面电荷特性发生变化，对伴刀豆球蛋白A和脂多糖的增殖反应受到抑制，以及通过混合淋巴细胞反应测量的抗原刺激激活受到抑制。对钥孔戚血蓝蛋白致敏的动物的淋巴细胞在利多卡因暴露终止8天后产生巨噬细胞移动抑制因子的能力显著降低。暴露于该药物的动物在受到外来物质（即葡聚糖）攻击的部位无法积累足够数量的免疫活性细胞，并且动物非特异性和特异性破坏肿瘤细胞的能力也受到损害。结果表明，长期暴露于利多卡因会导致淋巴细胞功能受损，即使在随后没有该药物的情况下也是如此，并且会导致免疫反应表达的显著变化。
