Dickstein R, Kiremidjian-Schumacher L, Stotzky G
Immunopharmacology. 1985 Jun;9(3):117-25. doi: 10.1016/0162-3109(85)90007-4.
In vitro exposure of mouse lymphocytes and macrophages for 24 h to noncytotoxic doses of lidocaine (10(-4) to 10(-6)M) resulted in inhibition of random macrophage motility and in an interference with the production of macrophage migration inhibitory factor or with its interaction with the cell surface. The effects of lidocaine, membrane-stabilizing local anesthetic, were related to its concentration in the medium and to its ability to interact with the cell surface and cause changes in the ionic configuration of the plasma membrane. The drug conferred permanent changes on the surface of lymphocytes at all concentrations tested, but changes in the surface of macrophages induced by 10(-5) and 10(-6)M lidocaine were reversible. The presence of noncytotoxic doses of lidocaine in the cellular environment resulted in significant changes in cellular functions that appeared to be related to the ability of the drug to interact with cell membranes in a manner determined by the specific properties of the cell.
将小鼠淋巴细胞和巨噬细胞在体外暴露于非细胞毒性剂量的利多卡因（10⁻⁴至10⁻⁶M）24小时，导致巨噬细胞随机运动受到抑制，并干扰巨噬细胞迁移抑制因子的产生或其与细胞表面的相互作用。利多卡因是一种膜稳定型局部麻醉剂，其作用与培养基中的浓度以及与细胞表面相互作用并引起质膜离子构型变化的能力有关。在所测试的所有浓度下，该药物都使淋巴细胞表面发生永久性变化，但10⁻⁵和10⁻⁶M利多卡因诱导的巨噬细胞表面变化是可逆的。细胞环境中存在非细胞毒性剂量的利多卡因会导致细胞功能发生显著变化，这些变化似乎与药物以由细胞特定特性决定的方式与细胞膜相互作用的能力有关。
