Greil W, Stoltzenburg M C, Mairhofer M L, Haag M
J Affect Disord. 1985 Jul;9(1):1-4. doi: 10.1016/0165-0327(85)90002-3.
Lithium dosage was examined in 3 age groups (less than or equal to 45 years, 46-64 years, greater than or equal to 65 years) of 78 inpatients, matched on relevant variables. Although mean steady-state lithium plasma levels showed no essential differences, mean daily lithium doses were significantly lower in the elderly. The ratio of weight-related lithium dose to plasma level showed a 36% decline with age (0.58, 0.46 and 0.37 1/kg, P less than 0.0001, analysis of variance). Comparing different decades this ratio, indicating the dose required for a certain plasma level, displayed a clear-cut decrease at 50 years. This may be caused by age-related changes in apparent volume of distribution and/or in elimination half-life of lithium, the latter being the consequence of age-related decrease of glomerular filtration rate.
对78名住院患者按相关变量进行匹配，分为3个年龄组（小于或等于45岁、46 - 64岁、大于或等于65岁），检测锂剂量。尽管平均稳态锂血浆水平无本质差异，但老年人的平均每日锂剂量显著更低。与体重相关的锂剂量与血浆水平的比值随年龄下降了36%（分别为0.58、0.46和0.37 1/kg，方差分析，P<0.0001）。比较不同十年，该比值（表明达到某一血浆水平所需的剂量）在50岁时明显下降。这可能是由于锂的表观分布容积和/或消除半衰期随年龄变化所致，后者是肾小球滤过率随年龄下降的结果。
