Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Qld, Australia.
Immunol Rev. 2020 Jan;293(1):115-143. doi: 10.1111/imr.12814. Epub 2019 Oct 14.
A century of conceptual and technological advances in infectious disease research has changed the face of medicine. However, there remains a lack of effective interventions and a poor understanding of host immunity to the most significant and complex pathogens, including malaria. The development of successful interventions against such intractable diseases requires a comprehensive understanding of host-pathogen immune responses. A major advance of the past decade has been a paradigm switch in thinking from the contemporary reductionist (gene-by-gene or protein-by-protein) view to a more holistic (whole organism) view. Also, a recognition that host-pathogen immunity is composed of complex, dynamic interactions of cellular and molecular components and networks that cannot be represented by any individual component in isolation. Systems immunology integrates the field of immunology with omics technologies and computational sciences to comprehensively interrogate the immune response at a systems level. Herein, we describe the system immunology toolkit and report recent studies deploying systems-level approaches in the context of natural exposure to malaria or controlled human malaria infection. We contribute our perspective on the potential of systems immunity for the rational design and development of effective interventions to improve global public health.
一个世纪以来，传染病研究在概念和技术上的进步改变了医学的面貌。然而，对于包括疟疾在内的最重大和最复杂的病原体，仍然缺乏有效的干预措施和对宿主免疫的深入理解。要开发针对这些棘手疾病的成功干预措施，需要全面了解宿主-病原体免疫反应。过去十年的一个重大进展是，人们的思维从当代的还原论（逐基因或逐蛋白）观点发生了转变，转向了更整体的（整个生物体）观点。此外，人们认识到宿主-病原体免疫是由细胞和分子成分以及网络的复杂、动态相互作用组成的，而不能仅由任何单个成分孤立地表示。系统免疫学将免疫学领域与组学技术和计算科学相结合，从系统水平全面探究免疫反应。本文中，我们描述了系统免疫学工具包，并报告了最近在自然感染疟疾或人为受控疟疾感染背景下应用系统方法的研究。我们贡献了我们对系统免疫的潜力的看法，即可以合理设计和开发有效的干预措施，以改善全球公共卫生。
