[放射性药物与治疗剂之间的相互作用。青霉胺对99mTc-亚甲基二膦酸盐分布的影响]
[Interaction between radiopharmaceutical and therapeutic agents. The modification of the distribution of 99mTc-methylene diphosphonate by D-penicillamine].
作者信息
Van de Flierdt E, Stumpf E, Bögl W
出版信息
Nuklearmedizin. 1985 Apr;24(2):82-6.
The effect of D-penicillamine on the distribution of 99mTc-MDP was studied in male Wistar rats. There were significant activity decreases after medication in blood, kidney, lung and skeletal muscle. The activity in the skeleton was not influenced by D-penicillamine. After treatment, the liver showed a significant increase of activity. The clearance of activity not bound to the skeleton altogether accelerates after D-penicillamine medication. It is assumed that the change of kinetics is caused by a complex formation of the radiopharmaceutical and D-penicillamine. D-penicillamine possibly displaces methylene diphosphonate from the 99mTc-complex.
在雄性Wistar大鼠中研究了D-青霉胺对99mTc-MDP分布的影响。用药后，血液、肾脏、肺和骨骼肌中的活性显著降低。骨骼中的活性不受D-青霉胺的影响。治疗后，肝脏的活性显著增加。D-青霉胺用药后，未与骨骼结合的活性清除总体加速。推测动力学变化是由放射性药物与D-青霉胺形成复合物所致。D-青霉胺可能从99mTc复合物中取代亚甲基二膦酸盐。
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