[Interaction between radiopharmaceutical and therapeutic agents. The modification of the distribution of 99mTc-methylene diphosphonate by D-penicillamine].

The effect of D-penicillamine on the distribution of 99mTc-MDP was studied in male Wistar rats. There were significant activity decreases after medication in blood, kidney, lung and skeletal muscle. The activity in the skeleton was not influenced by D-penicillamine. After treatment, the liver showed a significant increase of activity. The clearance of activity not bound to the skeleton altogether accelerates after D-penicillamine medication. It is assumed that the change of kinetics is caused by a complex formation of the radiopharmaceutical and D-penicillamine. D-penicillamine possibly displaces methylene diphosphonate from the 99mTc-complex.