Bevan J A, Tofe A J, Benedict J J, Francis M D, Barnett B L
J Nucl Med. 1980 Oct;21(10):961-6.
Technetium-99m hydroxymethylene diphosphonate (Tc-99M HMDP) is a new diphosphonate skeletal imaging agent. Animal studies show that Tc-99m HMDP has a higher uptake on bone and a more rapid clearance from the blood than any of the three technetium-labeled bone imaging agents in current use: Tc-99m methylene diphosphonate (DMP), Tc-99 (1-hydroxyethylidene) diphosphonate (HEDP), and Tc-99m pyrophosphate (PPi). On the basis of these animal studies, Tc-99m HMDP is a highly promising candidate for skeletal imaging.
锝-99m 羟亚甲基二膦酸盐（Tc-99m HMDP）是一种新型二膦酸盐骨显像剂。动物研究表明，与目前使用的三种锝标记骨显像剂：锝-99m 亚甲基二膦酸盐（DMP）、锝-99（1-羟基亚乙基）二膦酸盐（HEDP）和锝-99m 焦磷酸盐（PPi）相比，Tc-99m HMDP 在骨上的摄取更高，从血液中的清除更快。基于这些动物研究，Tc-99m HMDP 是骨显像极具前景的候选药物。
