Department of Health and Human Performance, University of Houston, Houston, TX, USA.
Center for Neuromotor and Biomechanics Research, University of Houston, Houston, TX, USA.
Disabil Rehabil. 2021 Jun;43(11):1585-1593. doi: 10.1080/09638288.2019.1674389. Epub 2019 Oct 15.
Individuals with Rett syndrome suffer from severely impaired cognitive and motor performance. Current movement-related therapeutic programs often include traditional physical therapy activities and assisted treadmill walking routines for those individuals who are ambulatory. However, there are no quantitative reports of kinematic gait parameters obtained during treadmill walking. The purpose of this research was to characterize the kinematic patterns of the lower limbs during treadmill walking as speed was slowly increased.
Seventeen independently ambulatory females diagnosed with a methyl-CpG-binding protein 2 gene mutation walked on a motorized treadmill while joint kinematics were obtained by a camera-based motion capture system and analysis software.
Stride times progressively decreased as treadmill speeds increased. There were significant main effects of speed on sagittal knee and hip ranges of motion and hip velocity. There were large joint asymmetries and variance values relative to other ambulatory patient populations, although variance values decreased as walking speed increased.
The results indicate that individuals with Rett syndrome can adapt their kinematic gait patterns in response to increasing treadmill speed, but only within a narrow range of speeds. We suggest that treadmill training for ambulatory individuals with Rett syndrome may promote improved walking kinematics and possibly provide overall health benefits.Implications for rehabilitationWalking is an activity that can counter the negative impacts of the sedentary lifestyle of many individuals with disabilities, including those individuals with Rett syndrome.Documentation of the lower limb kinematic patterns displayed during walking by ambulatory females with Rett syndrome can be used by clinicians to evaluate their patients' gait performance in response to therapeutic and pharmacological interventions designed to promote walking.The ability to adapt to increases in treadmill speed suggests that a training program of treadmill walking may be effective in promoting improved gait performance in individuals with Rett syndrome.
雷特综合征患者的认知和运动功能严重受损。目前的运动相关治疗方案通常包括传统的物理治疗活动和辅助跑步机步行程序，适用于那些能够行走的患者。然而，目前还没有关于在跑步机上行走时获得的运动学步态参数的定量报告。本研究的目的是描述在跑步机上行走时下肢的运动学模式，因为速度会逐渐增加。
17 名被诊断患有甲基-CpG 结合蛋白 2 基因突变的独立行走的女性在电动跑步机上行走，同时通过基于摄像机的运动捕捉系统和分析软件获取关节运动学。
随着跑步机速度的增加，步幅时间逐渐减少。速度对矢状面膝关节和髋关节运动范围以及髋关节速度有显著的主要影响。存在较大的关节不对称性和相对于其他可步行患者群体的方差值，尽管随着步行速度的增加，方差值减小。
结果表明，雷特综合征患者可以适应增加的跑步机速度来调整他们的运动学步态模式，但只能在较窄的速度范围内。我们建议，对于可步行的雷特综合征患者进行跑步机训练可能会促进改善步行运动学，并可能提供整体健康益处。
行走是一种活动，可以对抗许多残疾人士，包括雷特综合征患者，久坐不动的生活方式的负面影响。记录可步行的雷特综合征女性在行走时显示的下肢运动学模式，可以由临床医生用于评估他们的患者的步态表现，以响应旨在促进行走的治疗和药物干预。适应跑步机速度增加的能力表明，跑步机行走训练计划可能有效促进雷特综合征患者的步态表现改善。
