Vergain D E, Fiore-Donno G
SSO Schweiz Monatsschr Zahnheilkd. 1979 May;89(5):425-42.
The clinical, radiological and histological aspects of acute histiocytosis X of Letterer-Siwe disease are reviewed after personal observation of such cases. In spite of many advanced hypotheses the etiopathogenesis of Histiocytosis X is wide open to research. The diagnosis became possible by the discovery of histiocyte cells of a special order, the X-bodies, under the E. M. Recent research allows a classification of Letterer-Siwe disease, Hand-Schüller-Christian disease, and the eosinophilic granuloma under the same nosologic grouping. Finally, the prognosis of the Letterer-Siwe disease-so far much in the dark-may be improved by a properly conducted therapy.
在对勒-雪病急性组织细胞增多症X进行个人观察后，对其临床、放射学和组织学方面进行了综述。尽管有许多先进的假说，但组织细胞增多症X的病因发病机制仍有待深入研究。通过在电子显微镜下发现一种特殊类型的组织细胞即X小体，才使诊断成为可能。最近的研究允许将勒-雪病、汉-许-克病和嗜酸性肉芽肿归为同一疾病分类组。最后，通过适当的治疗，迄今仍不明朗的勒-雪病的预后可能会得到改善。
