Kim Ki-Hoon, Choi Chang-Bon, Kim Jong-Yeon
Department of Leisure & Sports, Kyungpook National University, Sangju, Korea.
School of Biotechnology, Yeungnam University, Gyeongsan, Korea.
Yeungnam Univ J Med. 2018 Dec;35(2):213-218. doi: 10.12701/yujm.2018.35.2.213. Epub 2018 Dec 31.
Body fats, especially both of abdominal fat pad mass and skeletal muscle fat content, are inversely related to insulin action. Therefore, methods for decreasing visceral fat mass and muscle triglyceride content may be helpful for the prevention of insulin resistance.
Thalidomide, used for its anti-angiogenic and anti-inflammatory properties, was administered to rats for 4 weeks. A 10% solution of thalidomide in dimethyl sulfoxide was injected daily into the peritoneal cavity as much as 100 mg/kg of body weight.
The total visceral fat pad mass in the thalidomide-treated group was 11% lower than in the control group. The size of adipocytes of the epididymal fat pad mass in the thalidomide-treated group was smaller than in the control group. The intraperitoneal thalidomide treatment increased triglyceride concentrations by 16% in the red muscle, but not in the white muscle.
The results suggested that intraperitoneal thalidomide treatment inhibited abdominal fat accumulation, and that the free fatty acids in the blood were preferentially accumulated in the red muscle rather than in the white muscle.
身体脂肪，尤其是腹部脂肪垫质量和骨骼肌脂肪含量，均与胰岛素作用呈负相关。因此，降低内脏脂肪量和肌肉甘油三酯含量的方法可能有助于预防胰岛素抵抗。
沙利度胺因其抗血管生成和抗炎特性，对大鼠给药4周。将沙利度胺在二甲基亚砜中的10%溶液每日腹腔注射，剂量为100毫克/千克体重。
沙利度胺治疗组的总内脏脂肪垫质量比对照组低11%。沙利度胺治疗组附睾脂肪垫质量的脂肪细胞大小比对照组小。腹腔注射沙利度胺使红色肌肉中的甘油三酯浓度增加了16%，但白色肌肉中未增加。
结果表明，腹腔注射沙利度胺可抑制腹部脂肪堆积，且血液中的游离脂肪酸优先堆积在红色肌肉而非白色肌肉中。
