钯催化芳酸的羧酸盐辅助乙氧基羧化反应：用溴二氟乙酸乙酯合成邻苯二甲酸单乙酯衍生物

Palladium-Catalyzed Carboxylate-Assisted Ethoxycarboxylation of Aromatic Acids To Synthesize Monoethyl Phthalate Derivatives with Ethyl Bromodifluoroacetate.

作者信息

Tao Na, Wang Jie, Yuan Chunchen, Zeng Runsheng, Zhao Ying-Sheng

机构信息

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science , Soochow University , Suzhou 215123 , China.

出版信息

Org Lett. 2019 Nov 1;21(21):8607-8610. doi: 10.1021/acs.orglett.9b03196. Epub 2019 Oct 17.

DOI:10.1021/acs.orglett.9b03196

PMID:31621337

Abstract

A novel and efficient approach for direct carbonation of aromatic acids with ethyl bromodifluoroacetate as the carbonyl source is reported. A broad range of substrates bearing various functional groups were tolerated, leading to monoalkyl phthalate derivatives in moderate to good yields.

摘要

报道了一种以溴二氟乙酸乙酯作为羰基源，直接使芳香酸羧基化的新颖且高效的方法。带有各种官能团的多种底物均适用，可中等至良好收率地得到单烷基邻苯二甲酸酯衍生物。