铜介导的钯催化 3-碘色酮、硫色酮和喹诺酮与溴二氟乙酸乙酯的交叉偶联反应。
Copper-mediated, palladium-catalyzed cross-coupling of 3-iodochromones, thiochromones, and quinolones with ethyl bromodifluoroacetate.
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, People's Republic of China.
出版信息
J Org Chem. 2013 May 17;78(10):4850-6. doi: 10.1021/jo400412k. Epub 2013 Apr 30.
PMID:23594098
Abstract
The palladium-catalyzed cross-coupling reaction of 3-iodochromones, thiochromones, and quinolones with ethyl bromodifluoroacetate in the presence of a copper mediator is reported. Under optimized conditions, all reactions worked well and provided difluoro-containing products in moderate to excellent yields.
摘要
报道了钯催化的 3-碘色酮、硫色酮和喹诺酮与溴二氟乙酸乙酯的交叉偶联反应，在铜介导剂的存在下进行。在优化条件下，所有反应都进行得很好，以中等至优异的收率提供了含二氟的产物。
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