具有16号染色体倒位——inv(16)(p13q22)——的白血病患者在16q22处是否有一个罕见的脆性位点？

Do leukemia patients with chromosome 16 inversion--inv(16)(p13q22)--have a rare fragile site at 16q22?

作者信息

Ohyashiki K, Ohyashiki J H, Toyama K, Ito H

机构信息

Department of Internal Medicine, Tokyo Medical College, Japan.

出版信息

Cancer Genet Cytogenet. 1988 Mar;31(1):31-4. doi: 10.1016/0165-4608(88)90007-6.

DOI:10.1016/0165-4608(88)90007-6

PMID:3162187

Abstract

Chromosomes were examined in the peripheral blood cells from three cases of acute myelomonocytic leukemia (AMMoL) with inv(16)(p13q22) in order to induce the rare fragile site at 16q22 [fra(16)(q22)] with distamycin-A and berenil. No chromosomal gaps, breaks, or reaRrangements at 16q22 were noted in lymphocytes treated from these cases, indicating that AMMoL patients with inv(16)(p13q22) do not always have the rare fragile site FRA16B, FRA(16)(q22). A predisposition to neoplasia in carriers of this fragile site is questionable.

摘要

对3例伴有inv(16)(p13q22)的急性粒单核细胞白血病（AMMoL）患者的外周血细胞进行染色体检查，以便用偏端霉素A和贝尼尔诱导16q22处罕见的脆性位点[fra(16)(q22)]。在这些病例的处理淋巴细胞中未发现16q22处有染色体间隙、断裂或重排，这表明伴有inv(16)(p13q22)的AMMoL患者并非总是有罕见的脆性位点FRA16B，即FRA(16)(q22)。这种脆性位点携带者发生肿瘤的易感性值得怀疑。