Simmers R N, Sutherland G R, West A, Richards R I
Science. 1987 Apr 3;236(4797):92-4. doi: 10.1126/science.3470945.
There is much speculation about fragile sites on human chromosomes predisposing to specific chromosome rearrangements seen in cancer. Acute myelomonocytic leukemia is characterized by neoplastic chromosome rearrangements involving band 16q22 in patients who carry the rare fragile site at 16q22. This specific leukemic breakpoint is within the metallothionein gene cluster, which is here shown to be proximal to the rare fragile site (FRA16B) and to a common fragile site (FRA16C) in this region. Hence neither of these fragile sites are at the breakpoint in this leukemic chromosomal rearrangement.
关于人类染色体上的脆性位点，人们有很多猜测，这些位点易导致在癌症中出现的特定染色体重排。急性粒单核细胞白血病的特征是，在携带位于16q22的罕见脆性位点的患者中，出现涉及16q22带的肿瘤性染色体重排。这个特定的白血病断点位于金属硫蛋白基因簇内，此处显示该基因簇在该区域中靠近罕见脆性位点（FRA16B）和一个常见脆性位点（FRA16C）。因此，在这种白血病染色体重排中，这些脆性位点均不在断点处。
