自闭症谱系障碍与微小RNA：实验模型概述
Autism Spectrum Disorder and miRNA: An Overview of Experimental Models.
作者信息
Schepici Giovanni, Cavalli Eugenio, Bramanti Placido, Mazzon Emanuela
机构信息
IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.
出版信息
Brain Sci. 2019 Oct 3;9(10):265. doi: 10.3390/brainsci9100265.
Abstract
Autism spectrum disorder (ASD) is a complex neuropsychiatric disorder characterized by deficits in social interactions, communication, language, and in a limited repertoire of activities and interests. The etiology of ASD is very complex. Genetic, epigenetic, and environmental factors contribute to the onset of ASD. Researchers have shown that microRNAs (miRNAs) could be one of the possible causes associated with ASD. miRNAs are small noncoding mRNAs that regulate gene expression, and they are often linked to biological processes and implicated in neurodevelopment. This review aims to provide an overview of the animal models and the role of the different miRNAs involved in ASD. Therefore, the use of animal models that reproduce the ASD and the identification of miRNAs could be a useful predictive tool to study this disorder.
摘要
自闭症谱系障碍（ASD）是一种复杂的神经精神疾病，其特征在于社交互动、沟通、语言方面存在缺陷，以及活动和兴趣范围有限。ASD的病因非常复杂。遗传、表观遗传和环境因素都对ASD的发病有影响。研究人员表明，微小RNA（miRNA）可能是与ASD相关的可能原因之一。miRNA是调节基因表达的小非编码mRNA，它们通常与生物过程相关，并参与神经发育。本综述旨在概述参与ASD的动物模型以及不同miRNA的作用。因此，使用能够重现ASD的动物模型并鉴定miRNA可能是研究这种疾病的有用预测工具。
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