凋亡 Caspases：在放射诱导免疫原性中的双刃剑。

Apoptotic Caspases: A Double-Edged Sword in Radiation-Induced Immunogenicity.

机构信息

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

出版信息

Trends Cell Biol. 2019 Nov;29(11):851-853. doi: 10.1016/j.tcb.2019.09.001. Epub 2019 Oct 14.

DOI:10.1016/j.tcb.2019.09.001

Abstract

In a recent study in Oncoimmunology, Rodriguez-Ruiz et al. demonstrate that the apoptotic executioner caspase 3 (CASP3) attenuates antitumor immune responses induced by radiation therapy (RT) by inhibiting the release of cytosolic DNA. CASP3 stands out as a promising target for the development of novel strategies to improve anticancer responses driven by RT.

摘要

在最近发表在《肿瘤免疫学》上的一项研究中，Rodriguez-Ruiz 等人证明，凋亡执行者半胱天冬酶 3（CASP3）通过抑制细胞质 DNA 的释放来减弱放射治疗（RT）诱导的抗肿瘤免疫反应。CASP3 是开发新策略以改善 RT 驱动的抗癌反应的有前途的靶点。