TREX1 降低癌症免疫原性。
TREX1 Cuts Down on Cancer Immunogenicity.
机构信息
Department of Radiation Oncology, Weill Cornell Medical College, 10065 New York, NY, USA.
Department of Radiation Oncology, Weill Cornell Medical College, 10065 New York, NY, USA; Sandra and Edward Meyer Cancer Center, 10065 New York, NY, USA; Université Paris Descartes/Paris V, 75006 Paris, France.
出版信息
Trends Cell Biol. 2017 Aug;27(8):543-545. doi: 10.1016/j.tcb.2017.06.001. Epub 2017 Jun 15.
Demaria and colleagues have recently identified three prime repair exonuclease 1 (TREX1) as a key determinant for the limited immunogenicity of cancer cells responding to single high-dose radiation. TREX1 stands out as a promising target for the development of novel strategies to boost anticancer immune responses driven by radiation therapy (RT).
德马里亚和同事最近发现，三引物修复外切酶 1（TREX1）是影响癌细胞对单次高剂量辐射产生有限免疫原性的关键决定因素。TREX1 是一个很有前途的靶点，可用于开发新的策略，增强由放射治疗（RT）驱动的抗癌免疫反应。
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