Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Br J Haematol. 2020 Feb;188(4):516-521. doi: 10.1111/bjh.16222. Epub 2019 Oct 17.
Primary central nervous system lymphoma (PCNSL) risk is highly increased in immunosuppressed individuals, such as those with human immunodeficiency virus infection and solid organ transplant recipients, but rates are increasing among immunocompetent older adults (age ≥65 years). We utilized data from a large, nationally-representative cohort of older adults in the United States and found that PCNSL is significantly associated with systemic lupus erythematosus, polyarteritis nodusa, autoimmune hepatitis, myasthenia gravis and uveitis. Immunosuppressive drugs given to treat these conditions may increase PCNSL risk, but these associations cannot explain the observed temporal increase in PCNSL rates, given the low prevalence of these conditions.
原发性中枢神经系统淋巴瘤（PCNSL）在免疫抑制个体中的风险显著增加，例如人类免疫缺陷病毒感染和实体器官移植受者，但在免疫功能正常的老年人群体（年龄≥65 岁）中发病率也在上升。我们利用来自美国一个大型、具有全国代表性的老年人群体数据发现，PCNSL 与系统性红斑狼疮、结节性多动脉炎、自身免疫性肝炎、重症肌无力和葡萄膜炎显著相关。为治疗这些疾病而使用的免疫抑制剂可能会增加 PCNSL 的风险，但鉴于这些疾病的低患病率，这些关联并不能解释观察到的 PCNSL 发病率的时间性增加。
