Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, AL, USA.
Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, AL, USA.
Pharmacol Ther. 2020 Jan;205:107424. doi: 10.1016/j.pharmthera.2019.107424. Epub 2019 Oct 16.
Amplified innate leukocytes (neutrophils and monocytes/macrophages) are associated with advanced ischemic and non-ischemic heart failure (HF). Intensified neutrophilic leukocytosis (neutrophilia) and sustained activation of neutrophils is the predominant factor that determines over activated inflammation in acute HF and the outcome of long-term chronic HF. After heart attack, the first wave of innate responsive and short-lived neutrophils is essential for the initiation of inflammation, resolution of inflammation, and cardiac repair, however uncontrolled and long-term activation of neutrophils leads to collateral damage of myocardium. In the presented review, we highlighted the interactive and integrative role of neutrophil phenotypes in cellular and molecular events of ischemic HF. In addition, we discussed the current, nonimmune, immune, and novel paradigms of neutrophils in HF associated with differential factors with a specific interest in non-resolving inflammation and resolution physiology.
扩增的固有白细胞（中性粒细胞和单核细胞/巨噬细胞）与晚期缺血性和非缺血性心力衰竭（HF）相关。强烈的中性粒细胞增多症（中性粒细胞增多）和中性粒细胞的持续激活是决定急性 HF 中过度激活炎症和长期慢性 HF 结局的主要因素。在心脏病发作后，先天反应性和短暂存活的中性粒细胞的第一波对于炎症的启动、炎症的消退和心脏修复是必要的，然而，中性粒细胞的不受控制和长期激活会导致心肌的附带损伤。在本综述中，我们强调了中性粒细胞表型在缺血性 HF 的细胞和分子事件中的相互作用和整合作用。此外，我们讨论了目前、非免疫、免疫和新型中性粒细胞在 HF 中的作用，以及与非解决炎症和解决生理学相关的差异因素的关注。
