Resegotti L, Palestro G, Pistone M A, Diana A, Dolci C, Leonardo E, Testa D
Arch Sci Med (Torino). 1979 Apr-Jun;136(2):265-74.
In view of some data of the literature suggesting that immunological changes could play a role in the pathogensis of diabetes mellitus and of its complications, we carried out a study of the lymphocyte populations of 44 diabetic subjects by means of E, EA, EAC rosettes and membrane immunofluorescence. A quarter of the patients had decreased E rosettes: all of these had long-lasting, insulin-dependent, poorly controlled diabetes. Some of these patients had also increased membrane IgG globulins. In 5 patients with recent onset, insulin-independent diabetes, E rosettes were increased. No significant changes of EA and EAC rosettes were observed. These findings suggest that changes of lymphocyte populations do not play any role in the pathogenesis of diabetes, while these may be the consequence of the metabolic disorder and these may favour the onset of complications of the disease.
鉴于文献中的一些数据表明免疫变化可能在糖尿病及其并发症的发病机制中起作用，我们通过E、EA、EAC玫瑰花结试验和膜免疫荧光对44例糖尿病患者的淋巴细胞群体进行了研究。四分之一的患者E玫瑰花结减少：所有这些患者都患有病程长、胰岛素依赖且控制不佳的糖尿病。其中一些患者的膜IgG球蛋白也增加。在5例新近发病、非胰岛素依赖型糖尿病患者中，E玫瑰花结增加。未观察到EA和EAC玫瑰花结有显著变化。这些发现表明淋巴细胞群体的变化在糖尿病发病机制中不起任何作用，而这些变化可能是代谢紊乱的结果，并且可能有利于疾病并发症的发生。
