胚胎移植实验：过去、现在与未来。
Embryonic transplantation experiments: Past, present, and future.
作者信息
Solini Grace E, Dong Chen, Saha Margaret
机构信息
Biology Department, The College of William and Mary, integrated Science Center, 540 Landrum Dr., Williamsburg, VA 23185, USA.
出版信息
Trends Dev Biol. 2017;10:13-30.
Abstract
The process of taking a piece of tissue and transplanting it into a novel location has been of paramount importance for life sciences. The technique of transplantation has served an important role in providing a basic understanding of all facets of biology ranging from cancer and evolutionary biology to developmental biology. First employed by early embryologists, transplantation has played a particularly critical role in elucidating virtually every aspect of embryonic development including cell specification, commitment, cell fate determination, embryonic induction, and plasticity. This review will detail the essential role cell transplantation experiments have played in uncovering fundamental developmental and cell biological processes as well as their valuable contribution to contemporary developmental biology. Finally, it will suggest fruitful directions that this technique, in conjunction with current molecular and sequencing technologies, could play in future work.
摘要
获取一块组织并将其移植到新位置的过程对生命科学至关重要。移植技术在提供对从癌症、进化生物学到发育生物学等生物学各个方面的基本理解方面发挥了重要作用。移植最早由早期胚胎学家采用，在阐明胚胎发育的几乎每个方面，包括细胞特化、定向、细胞命运决定、胚胎诱导和可塑性等方面发挥了特别关键的作用。本综述将详细阐述细胞移植实验在揭示基本发育和细胞生物学过程中所起的重要作用，以及它们对当代发育生物学的宝贵贡献。最后，将提出这项技术与当前分子和测序技术相结合在未来工作中可能发挥作用的富有成效的方向。
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