Emran N, Sommer A
Arch Ophthalmol. 1979 Dec;97(12):2333-5. doi: 10.1001/archopht.1979.01020020549009.
Lissamine green staining of the conjunctiva, a new and widely heralded aid for diagnosing early xerophthalmia, was found to be a reasonably specific but inadequately sensitive test for practical use. While 82% of clinically normal children failed to show staining, so did 57% with night blindness, 29% with vitamin A responsive Bitot's spots, and, most significantly, 26% with severe, vitamin A related corneal involvement. The test also failed to distinguish vitamin A responsive "Bitot's spots" from nonresponsive ones.
结膜的丽丝胺绿染色，一种新近备受推崇的早期干眼症诊断辅助方法，被发现是一种在实际应用中具有一定特异性但灵敏度不足的检测方法。虽然82%临床正常的儿童未出现染色，但57%患有夜盲症的儿童、29%患有对维生素A有反应的毕脱斑的儿童，以及最显著的是26%患有严重的、与维生素A相关的角膜病变的儿童也未出现染色。该检测方法也无法区分对维生素A有反应的“毕脱斑”和无反应的毕脱斑。
