Wang Yang, Liu Yan, Zhou Kehua, Bauer Brent A, Liu Baoyan, Su Tongsheng, Mo Qian, Liu Zhishun
Acupuncture Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Therap Adv Gastroenterol. 2019 Oct 9;12:1756284819881859. doi: 10.1177/1756284819881859. eCollection 2019.
Electroacupuncture (EA) has been shown to improve complete spontaneous bowel movements (CSBMs), but the duration of its effects remains unknown. The objective of this study was to explore the duration of acupuncture effects after treatment and its associated factors for chronic severe functional constipation (CSFC).
This was a secondary analysis of a multicenter, randomized, sham-acupuncture (SA) controlled trial that included 1075 participants with CSFC. The primary outcome, the duration of acupuncture effects after treatment, was the number of weeks during the 12-week follow-up period that participants were to meet the weekly CSBM responder criteria. A weekly CSBM responder was defined as a participant who had at least three CSBMs for a given week and an increase from baseline of at least one CSBM for that same week. We performed a retrospective multivariate analysis to explore potential factors associated with sustained acupuncture effects.
The duration of acupuncture effects in the EA group (5.5 weeks) was significantly higher than the duration of SA effects in the SA group (2.2 weeks) with a between-group difference of 3.2 weeks (95% CI, 2.77-3.78; < 0.001). A younger age and higher baseline CSBMs per week [regression coefficient (RC) -0.06, 95% confidence interval (CI) (-0.06 to -0.04); RC 2.43, 95% CI 1.78-3.60; respectively] were associated with longer durations of acupuncture effects.
EA had sustained post-treatment effects for CFSC. A significant association among a younger age, higher baseline CSBMs and sustained acupuncture effects was observed. Further research is needed to confirm the association.
ClinicalTrials.gov (NCT01726504). Registered on 26 August 2012.
电针已被证明可改善完全自主排便（CSBM），但其效果持续时间尚不清楚。本研究的目的是探讨慢性严重功能性便秘（CSFC）患者治疗后针刺效果的持续时间及其相关因素。
这是一项对多中心、随机、假针刺（SA）对照试验的二次分析，该试验纳入了1075例CSFC患者。主要结局指标为治疗后针刺效果的持续时间，即12周随访期内患者达到每周CSBM反应标准的周数。每周CSBM反应者定义为在给定周内至少有三次CSBM且该周CSBM较基线增加至少一次的患者。我们进行了回顾性多变量分析，以探讨与针刺效果持续存在相关的潜在因素。
电针组针刺效果持续时间（5.5周）显著高于假针刺组的SA效果持续时间（2.2周），组间差异为3.2周（95%CI，2.77 - 3.78；P < 0.001）。年龄较小和每周基线CSBM次数较多[回归系数（RC）-0.06，95%置信区间（CI）（-0.06至-0.04）；RC 2.43，95%CI 1.78 - 3.60]与针刺效果持续时间较长相关。
电针治疗CSFC有持续的治疗后效果。观察到年龄较小、基线CSBM次数较多与针刺效果持续存在之间存在显著关联。需要进一步研究来证实这种关联。
ClinicalTrials.gov（NCT01726504）。于2012年8月26日注册。
