甲型肝炎病毒相关儿科肝病负担及其在印度次大陆的意义。
Hepatitis A Virus-related Pediatric Liver Disease Burden and its Significance in the Indian Subcontinent.
机构信息
Department of Pediatric Hepatology Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India.
Department of Clinical Virology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India.
出版信息
Indian Pediatr. 2019 Sep 15;56(9):741-744.
OBJECTIVE
To study the Hepatitis A virus (HAV) infection-related pediatric liver disease burden.
METHODS
Hospital records of 431 children (age <18 y) diagnosed to be suffering from acute HAV infection during 2011 to 2018 were extracted and analyzed. Additionally, a seroprevalence study was done on 2599 participants (696 children and 1903 adults).
RESULTS
HAV infection accounted for about half (48.6% of acute hepatitis and 46.5% (92/198) of acute liver failure cases) of all acute onset icteric illness, with significant morbidity and mortality. As per seroprevalence data, 16.2% of children between 10-18 years of age, and 10.3% of adults aged 18-30 years remained susceptible to HAV infection.
CONCLUSIONS
HAV infection is the major contributor the overall pediatric liver disease burden. A significant proportion of subjects remain susceptible to HAV infection even after 10 years of age. Population-based studies are required to further delineate the epidemiology of HAV infection in India for deciding introduction of HAV vaccine in the national immunization schedule.
目的
研究甲型肝炎病毒（HAV）感染相关的儿科肝病负担。
方法
提取并分析了 2011 年至 2018 年间诊断为急性 HAV 感染的 431 名儿童（年龄<18 岁）的住院记录。此外，对 2599 名参与者（696 名儿童和 1903 名成人）进行了血清流行率研究。
结果
HAV 感染占所有急性黄疸性疾病的一半左右（急性肝炎的 48.6%，急性肝衰竭的 46.5%（92/198）），具有较高的发病率和死亡率。根据血清流行率数据，10-18 岁的儿童中有 16.2%，18-30 岁的成年人中有 10.3%仍易感染 HAV。
结论
HAV 感染是儿科肝病总负担的主要原因。即使在 10 岁以后，仍有相当一部分人群易感染 HAV。需要进行基于人群的研究，以进一步阐明印度 HAV 感染的流行病学，从而决定是否将 HAV 疫苗纳入国家免疫计划。
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