Epilepsy Center, Cleveland Clinic, Cleveland, USA, Neurology section, University of Antioquia, Medellin, Colombia, Neuroclinica, Medellin, Colombia.
Epilepsy Center, Cleveland Clinic, Cleveland, USA.
Epileptic Disord. 2019 Oct 1;21(5):479-482. doi: 10.1684/epd.2019.1103.
Antiepileptic drug side effects are frequent, 42% of them corresponding to cosmetic changes. The most frequent effects are weight gain, gingival hyperplasia, and hair loss. Hair changes in texture or colour are rarely reported in the literature. We present a case of hair curling after the introduction of perampanel. A 13-year-old girl with genetically confirmed Pitt-Hopkins syndrome with uncontrolled seizures, while on treatment with levetiracetam and valproic acid, was started on perampanel, reaching seizure control. After a few weeks of the introduction of the new antiepileptic drug, she developed hair curling. Hair curling is a rare cosmetic side effect, reported mainly in patients under valproic acid treatment. Perampanel is a recently introduced pharmaceutical molecule with no prior reports of hair changes as a side effect. There is no clear explanation for this side effect, but it should be discussed with patients taking valproate whenever perampanel is added to the treatment.
抗癫痫药物的副作用很常见，其中 42%与美容变化有关。最常见的影响是体重增加、牙龈增生和脱发。毛发质地或颜色的变化在文献中很少报道。我们报告了一例在使用仑帕奈隆后出现卷发的病例。一名 13 岁女孩患有遗传性确认的 Pitt-Hopkins 综合征，伴有无法控制的癫痫发作，在接受左乙拉西坦和丙戊酸钠治疗的同时，开始使用仑帕奈隆，达到了控制癫痫发作的效果。在新的抗癫痫药物引入几周后，她出现了头发卷曲。头发卷曲是一种罕见的美容副作用，主要在接受丙戊酸钠治疗的患者中报告。仑帕奈隆是一种最近引入的药物分子，没有先前报告的毛发变化作为副作用。对于这种副作用没有明确的解释，但当丙戊酸钠治疗中添加仑帕奈隆时，应与患者讨论。
