Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, No. 53 Zhengzhou Rd, Qingdao, 266042, PR China.
Biomater Sci. 2019 Dec 1;7(12):4944-4962. doi: 10.1039/c9bm01305a. Epub 2019 Oct 25.
Oligonucleotides are widely used biological materials in the fields of biomedicine, nanotechnology, and materials science. Due to the demands for the photoregulation of DNA activities, scientists are placing more and more research interest in the interactions between reversible photochromic molecules and DNAs. Photochromic molecules can work as switches for regulating the DNAs' behavior under light irradiation; meanwhile, DNAs also exert influence over the photochromic molecules. The photochromic molecules can be attached to DNAs either by covalent bonds or by noncovalent forces, which results in different regulative functions. Azobenzenes, spiropyrans, diarylethenes, and stilbene-like compounds are important photochromic molecules working as photoswitches. By summarizing their interactions with oligonucleotides, this review intends to facilitate the relevant research on oligonucleotides/photochromic molecules in the biological and medicinal fields and in materials science.
寡核苷酸在生物医药、纳米技术和材料科学等领域被广泛应用。由于对 DNA 活性的光调控需求，科学家对可逆光致变色分子与 DNA 之间的相互作用越来越感兴趣。光致变色分子可以作为调控 DNA 在光照射下行为的开关；同时，DNA 也对光致变色分子施加影响。光致变色分子可以通过共价键或非共价键与 DNA 结合，从而产生不同的调节功能。偶氮苯、螺吡喃、二芳基乙烯和二苯乙烯类化合物是重要的光致变色分子，可作为光开关。通过总结它们与寡核苷酸的相互作用，本综述旨在促进寡核苷酸/光致变色分子在生物医学和材料科学领域的相关研究。
