Department of Ear, Nose, and Throat, Antalya Education and Training Hospital, Antalya, Turkey
Department of Ear, Nose, and Throat, Ankara Dışkapı Yıldırım Beyazıt Education and Training Hospital, Ankara, Turkey
Turk J Med Sci. 2019 Oct 24;49(5):1450-1454. doi: 10.3906/sag-1902-210.
BACKGROUND/AIM: This study was conducted to determine the critical partial oxygen pressure (pO2) value that would impair hearing function by evaluating the effects of hypoxia on hearing function in subjects diagnosed with chronic obstructive pulmonary disease (CPOD).
The study included 25 male and 5 female patients referred to our clinic who were diagnosed with COPD, according to spirometry and PaO2 values, and who did not show pathology upon autoscopic examination. The control group consisted of 14 female and 16 male patients who had no lung disease and were in the same age range as the COPD group.
A statistically significant difference was found between the two groups for distortion-product otoacoustic emission (DPOAE) (P < 0.001). The COPD group was divided into two groups according to pO2 levels (pO2 ≤ 70 and pO2 > 70) in order to find a critical pO2 level which might cause significant change at a certain audiological extent.
Hypoxia causes long-term decline in hearing thresholds, deterioration of DPOAE results, and prolongation of I–V interpeak latency in auditory brainstem response. However, the critical oxygen level that disrupts hearing function could not be determined.
背景/目的：本研究旨在通过评估缺氧对慢性阻塞性肺疾病（COPD）患者听力功能的影响，确定导致听力功能受损的临界部分氧分压（pO2）值。
本研究纳入了 25 名男性和 5 名女性患者，这些患者根据肺量计和 PaO2 值被诊断为 COPD，且在自动内窥镜检查中未发现病理学改变。对照组由 14 名女性和 16 名男性组成，他们没有肺部疾病，且年龄与 COPD 组相匹配。
两组间畸变产物耳声发射（DPOAE）（P < 0.001）存在统计学显著差异。为了找到可能在一定程度上导致显著变化的临界 pO2 水平，COPD 组根据 pO2 水平（pO2 ≤ 70 和 pO2 > 70）分为两组。
缺氧导致听力阈值长期下降、DPOAE 结果恶化以及听觉脑干反应中 I-V 峰间潜伏期延长。然而，未能确定破坏听力功能的临界氧水平。
