Kang Eun Seok, Jang Seohui, Kim Hye Jun, Kim Kyuwoong, Sha Meng, Oh Yun Hwan, Suh Michelle J, Jeong Seogsong
Department of Biomedical Informatics Korea University College of Medicine Seoul Republic of Korea.
Department of Biomedical Science CHA University Pocheon Republic of Korea.
Laryngoscope Investig Otolaryngol. 2025 May 10;10(3):e70156. doi: 10.1002/lio2.70156. eCollection 2025 Jun.
This study examined the association between metabolic dysfunction-associated steatotic liver disease (MASLD) and the risk of sudden sensorineural hearing loss (SSNHL) in elderly individuals.
A population-based cohort study using the Korean National Health Insurance Service-Senior cohort included 189,623 individuals aged 65 and older, categorized as non-SLD or MASLD. Cox proportional hazards regression and Fine-Gray subdistribution hazard models were used to evaluate the risk of SSNHL and Ménière's disease, considering all-cause mortality as a competing event.
Baseline characteristics showed that MASLD participants had higher metabolic dysfunction markers, including elevated body mass index, waist circumference, and blood pressure, compared to the non-SLD group. During 9 years of follow-up, 3803 SSNHL events occurred in the MASLD group, with an incidence rate of 2.44 per 1000 person-years. After inverse probability of treatment weighting, MASLD was associated with a significantly increased risk of SSNHL (adjusted hazard ratio: 1.05, 95% CI: 1.00-1.10; = 0.039; subdistribution hazard ratio: 1.06, 95% CI: 1.01-1.11; = 0.016).
MASLD is associated with an increased risk of SSNHL. This study provides evidence supporting a metabolic influence on auditory health, warranting further investigation into the liver-ear axis.
Step 3 (Level 3*)-Cohort study.
本研究探讨老年人群中代谢功能障碍相关脂肪性肝病（MASLD）与突发性感音神经性听力损失（SSNHL）风险之间的关联。
一项基于韩国国民健康保险服务老年队列的人群队列研究纳入了189,623名65岁及以上的个体，分为非脂肪性肝病（SLD）组或MASLD组。采用Cox比例风险回归模型和Fine-Gray亚分布风险模型评估SSNHL和梅尼埃病的风险，并将全因死亡作为竞争事件。
基线特征显示，与非SLD组相比，MASLD参与者具有更高的代谢功能障碍标志物，包括体重指数、腰围和血压升高。在9年的随访期间，MASLD组发生了3803例SSNHL事件，发病率为每1000人年2.44例。在进行治疗权重逆概率分析后，MASLD与SSNHL风险显著增加相关（调整后的风险比：1.05，95%置信区间：1.00-1.10；P = 0.039；亚分布风险比：1.06，95%置信区间：1.01-1.11；P = 0.016）。
MASLD与SSNHL风险增加相关。本研究提供了支持代谢对听觉健康有影响的证据，有必要进一步研究肝-耳轴。
第3步（3*级）——队列研究。
