Yao Jian-Hui, Li Wei-Min
Department of Critical Care Medicine.
Department of Emergency, Yulin No.1 Hospital, Yulin, China.
Medicine (Baltimore). 2019 Oct;98(43):e17644. doi: 10.1097/MD.0000000000017644.
The aim of this study is to explore the efficacy and safety of ulinastatin for the treatment of patients with severe acute pancreatitis (SAP).
We will search randomized controlled trials which assess the efficacy and safety of ulinastatin for patients with SAP from the electronic databases of Cochrane Library, MEDILINE, EMBASE, CINAHL, PsycINFO, Scopus, CBM, Wangfang, VIP, and CNKI. All electronic databases will be searched from inception to the present with no limitations of language and publication status. Two researchers will carry out study selection, data extraction, and study quality assessment independently. Another researcher will help to resolve any disagreements between 2 researchers.
The outcomes include overall mortality, time of hospital stay, complications of systematic or local infection, multiple organ deficiency syndrome, health related quality of life (as measured as the 36-Item Short Form Health Survey), and adverse events related to nutrition.
This study will provide evidence to evaluate the efficacy and safety of ulinastatin in the treatment of patients with SAP.
PROSPERO CRD42019149566.
本研究旨在探讨乌司他丁治疗重症急性胰腺炎（SAP）患者的疗效和安全性。
我们将从Cochrane图书馆、MEDILINE、EMBASE、CINAHL、PsycINFO、Scopus、中国生物医学文献数据库（CBM）、万方数据库、维普数据库和中国知网（CNKI）的电子数据库中检索评估乌司他丁治疗SAP患者疗效和安全性的随机对照试验。所有电子数据库将从建库至当前进行检索，不受语言和出版状态限制。两名研究人员将独立进行研究筛选、数据提取和研究质量评估。另一名研究人员将协助解决两名研究人员之间的任何分歧。
结局指标包括总死亡率、住院时间、全身或局部感染并发症、多器官功能障碍综合征、健康相关生活质量（采用36项简短健康调查问卷衡量）以及与营养相关的不良事件。
本研究将为评估乌司他丁治疗SAP患者的疗效和安全性提供证据。
国际前瞻性系统评价注册库（PROSPERO）CRD42019149566。
