Simonić A, Atanacković D, Batistić B
Department of Pharmacology, School of Medicine, University of Rijeka, Yugoslavia.
Scand J Rehabil Med Suppl. 1988;17:125-30.
Rabbits were made paraplegic by spinal cord contusion. There was a good correlation between motor function and microscopic findings. The spinal lesion significantly increased creatine kinase (CKBB) isoenzyme activity in cord tissue. Significant protection from paralysis was conveyed by piracetam (a psychoactive drug with neuroprotective activity) (2 g.kg-1 i.v.) administered once per day during 9 posttraumatic days. Piracetam significantly diminished increased activity of CKBB in the severed spinal cord. The sooner the piracetam was injected after the lesion the better protective effect was seen. No side effects of piracetam were seen.
通过脊髓挫伤使兔子发生截瘫。运动功能与微观检查结果之间存在良好的相关性。脊髓损伤显著增加了脊髓组织中肌酸激酶（CKBB）同工酶的活性。在创伤后的9天内，每天静脉注射一次吡拉西坦（一种具有神经保护活性的精神活性药物）（2 g·kg-1）可显著预防瘫痪。吡拉西坦显著降低了脊髓横断后CKBB活性的增加。损伤后越早注射吡拉西坦，保护效果越好。未观察到吡拉西坦的副作用。
