Simonić A, Atanacković D
Arch Int Pharmacodyn Ther. 1984 Dec;272(2):296-303.
Experimental, lumbal spinal cord compact injury provoked by a strike of 71 p.cm caused a spontaneously irreversible paraplegy in rabbits. Motor activity of injured rabbits was controlled during nine posttraumatic days. Piracetam significantly reduced motor dysfunction of the hind legs. Piracetam (2 g.kg-1) was given i.v., once per day during nine posttraumatic days. The beneficial effect of piracetam was more pronounced when the delay between trauma and the onset of drug administration was shorter. When this delay amounted to 360 minutes, piracetam did not influence significantly motor activity of contusioned animals. No side effects of piracetam were observed.
实验性地，用71磅厘米的撞击造成兔腰段脊髓压缩性损伤，引发了自发的、不可逆的截瘫。在创伤后的九天内对受伤兔子的运动活动进行了监测。吡拉西坦显著减轻了后腿的运动功能障碍。在创伤后的九天内，每天静脉注射一次吡拉西坦（2克/千克）。当创伤与给药开始之间的延迟较短时，吡拉西坦的有益效果更明显。当这种延迟达到360分钟时，吡拉西坦对挫伤动物的运动活动没有显著影响。未观察到吡拉西坦的副作用。
