Department of Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Department of Regenerative Medicine Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Int J Mol Sci. 2019 Oct 24;20(21):5270. doi: 10.3390/ijms20215270.
Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the involvement of Hh signaling in ischemic tissue regeneration and angiogenesis, with particular attention to the heart, the brain, and the skeletal muscle. Updated information on the potential role of the Hh pathway as a therapeutic target in the ischemic condition is also presented.
刺猬（Hh）蛋白是典型的形态发生素，已知在胚胎发育过程中调节上皮/间充质相互作用。除了在胚胎发生中的关键作用外，Hh 信号通路在许多生理和病理条件下，包括缺血，可能在出生后生命中重现。本综述强调了 Hh 信号在缺血组织再生和血管生成中的作用，特别关注心脏、大脑和骨骼肌。还介绍了 Hh 途径作为缺血情况下治疗靶点的潜在作用的最新信息。
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