Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Ave, Kowloon 999077, Hong Kong, China.
City University of Hong Kong Shenzhen Research Institute, Yuexing Yi Dao, Nanshan District, Shenzhen 518057, China.
Sensors (Basel). 2019 Oct 24;19(21):4632. doi: 10.3390/s19214632.
Optical resolution photoacoustic microscopy (OR-PAM) provides high-resolution, label-free and non-invasive functional imaging for broad biomedical applications. Dual-polarized fiber laser sensors have high sensitivity, low noise, a miniature size, and excellent stability; thus, they have been used in acoustic detection in OR-PAM. Here, we review recent progress in fiber-laser-based ultrasound sensors for photoacoustic microscopy, especially the dual-polarized fiber laser sensor with high sensitivity. The principle, characterization and sensitivity optimization of this type of sensor are presented. In vivo experiments demonstrate its excellent performance in the detection of photoacoustic (PA) signals in OR-PAM. This review summarizes representative applications of fiber laser sensors in OR-PAM and discusses their further improvements.
光学解析光声显微镜（OR-PAM）为广泛的生物医学应用提供了高分辨率、无标记和非侵入性的功能成像。双偏振光纤激光传感器具有高灵敏度、低噪声、微型化和优异的稳定性；因此，它们已被用于 OR-PAM 中的声检测。在这里，我们综述了基于光纤激光的光声显微镜超声传感器的最新进展，特别是具有高灵敏度的双偏振光纤激光传感器。介绍了这种传感器的原理、特性和灵敏度优化。体内实验证明了它在 OR-PAM 中光声（PA）信号检测中的优异性能。本文综述了光纤激光传感器在 OR-PAM 中的代表性应用，并讨论了它们的进一步改进。
