Upputuri Paul Kumar, Pramanik Manojit
School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459 Singapore.
Biomed Eng Lett. 2018 Mar 6;8(2):167-181. doi: 10.1007/s13534-018-0060-9. eCollection 2018 May.
Photoacoustic imaging (PAI) is a newly emerging imaging modality for preclinical and clinical applications. The conventional PAI systems use Q-switched Nd:YAG/OPO (Optical Parametric Oscillator) nanosecond lasers as excitation sources. Such lasers are expensive, bulky, and imaging speed is limited because of low pulse repetition rate. In recent years, the semiconductor laser technology has advanced to generate high-repetitions rate near-infrared pulsed lasers diodes (PLDs) which are reliable, less-expensive, hand-held, and light-weight, about 200 g. In this article, we review the development and demonstration of PLD based PAI systems for preclinical and clinical applications reported in recent years.
光声成像（PAI）是一种新兴的用于临床前和临床应用的成像模态。传统的光声成像系统使用调Q钕：钇铝石榴石/光学参量振荡器（OPO）纳秒激光器作为激发源。这类激光器价格昂贵、体积庞大，并且由于脉冲重复率低，成像速度受限。近年来，半导体激光技术取得了进展，能够产生高重复率的近红外脉冲激光二极管（PLD），这些激光二极管可靠、成本较低、可手持且重量轻，约200克。在本文中，我们综述了近年来报道的基于脉冲激光二极管的光声成像系统在临床前和临床应用方面的发展与示范。
